2024
Development of 2-Aminotetralin-Type Serotonin 5-HT1 Agonists: Molecular Determinants for Selective Binding and Signaling at 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT1F Receptors
Ryan P. McGlynn, Meng Cui, Brittany Brems, Otto Holbrook, and Raymond G. Booth
2023
Effects of (-)-MBP, a novel 5-HT2C agonist and 5-HT2A/2B antagonist/inverse agonist on brain activity: A phMRI study on awake mice
Preeti K. Sathe, Gargi R. Ramdasi, Kaylie Giammatteo, Harvens Beauzile, Shuyue Wang, Heng Zhang, Praveen Kulkarni, Raymond G. Booth, Craig F. Ferris
Conformationally Selective 2-Aminotetralin Ligands Targeting the alpha2A- and alpha2C-Adrenergic Receptors
Nicholas R. Fragola, Brittany M. Brems, Munmun Mukherjee, Meng Cui, and Raymond G. Booth
Oxycodone self-administration and reinstatement in male and female squirrel monkeys: Effects of alternative reinforcer availability
Fernando B de Moura, Raymond G. Booth, and Stephen J Kohut
2022
FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT1A, 5-HT1B, and 5-HT1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 Knockout Mice
Tanishka S. Saraf, Ryan P. McGlynn, Omkar M. Bhatavdekar, Raymond G. Booth, and Clinton E. Canal
“Selective” serotonin 5-HT2A receptor antagonists
Austen B. Casey, Meng Cui, Raymond G. Booth, Clinton E. Canal
2021
A new class of 5-HT2A/5-HT2C receptor inverse agonists: Synthesis, molecular modeling, in vitro and in vivo pharmacology of novel 2-aminotetralins
Austen B. Casey, Munmun Mukherjee, Ryan P. McGlynn, Meng Cui, Stephen J. Kohut, Raymond G. Booth
Evaluation of lorcaserin as an anticonvulsant in juvenile Fmr1 knockout mice
Tanishka S. Saraf, Daniel E. Felsing, Jessica L. Armstrong, Raymond G. Booth, Clinton E. Canal
2020
(S)-5-(2′-Fluorophenyl)- N, N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Fmr1 Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder
Jessica L. Armstrong, Austen B. Casey, Tanishka S. Saraf, Munmun Mukherjee, Raymond G. Booth, Clinton E. Canal
Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT1A and 5-HT7 G protein-coupled receptor affinity, 3D-QSAR and molecular modeling
Charles K. Perry, Austen B. Casey, Daniel E. Felsing, Rajender Vemula, Mehreen Zaka, Noah B. Herrington, Meng Cui, Glen E. Kellogg, Clinton E. Canal, Raymond G. Booth
2019
Ligand-directed serotonin 5-HT2C receptor desensitization and sensitization
Daniel E. Felsing, Clinton E. Canal, Raymond G. Booth
2017
Mutagenesis Analysis Reveals Distinct Amino Acids of the Human Serotonin 5-HT2C Receptor Underlying the Pharmacology of Distinct Ligands
Yue Liu, Clinton E. Canal, Tania C. Cordova-Sintjago, Wanying Zhu, and Raymond G. Booth
2015
An Orally Active Phenylaminotetralin-Chemotype Serotonin 5-HT7 and 5-HT1A Receptor Partial Agonist that Corrects Motor Stereotypy in Mouse Models
Clinton E. Canal, Daniel E. Felsing, Yue Liu, Wanying Zhu, JodiAnne T. Wood, Charles K. Perry, Rajender Vemula, and Raymond G. Booth
Novel 4-substituted-N,N-dimethyltetrahydronaphthalen-2-amines: synthesis, affinity, and in silico docking studies at serotonin 5-HT2-type and histamine H1 G protein-coupled receptors
Rajeev Sakhuja, Krishnakanth Kondabolu, Tania Córdova-Sintjago, Sean Travers, Adam S. Vincek, Myong Sang Kim, Khalil A. Abboud, Lijuan Fang, Zhuming Sun, Clinton E. Canal, and Raymond G. Booth
Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens
James M Kasper, Raymond G. Booth, and Joanna Peris
2014
Aromatic interactions impact ligand binding and function at serotonin 5-HT2C G protein-coupled receptors: Receptor homology modeling, ligand docking, and molecular dynamics results validated by experimental studies
Tania Córdova-Sintjago, Nancy Villa, Lijuan Fang, and Raymond G. Booth
A novel aminotetralin-type serotonin (5-HT) 2C receptor-specific agonist and 5-HT2A competitive antagonist/5-HT2B inverse agonist with preclinical efficacy for psychoses
Clinton E. Canal, Drake Morgan, Daniel Felsing, Krishnakanth Kondabolu, Neil E. Rowland, Kimberly L. Robertson, Rajeev Sakhuja, and Raymond G. Booth
2013
Molecular pharmacology and ligand docking studies reveal a single amino acid difference between mouse and human serotonin 5-HT2A receptors that impacts behavioral translation of novel 4-phenyl-2-dimethylaminotetralin ligands
Clinton E. Canal, Tania Cordova-Sintjago, Yue Liu, Myong S. Kim, Drake Morgan, and Raymond G. Booth
Molecular and behavioral pharmacology of two novel orally-active 5HT2 modulators: potential utility as antipsychotic medications
Drake Morgan, Krishnakanth Kondabolu, Allison Kuipers, Rajeev Sakhuja, Kimberly L. Robertson, Neil E. Rowland, and Raymond G. Booth
Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response model
Clinton E. Canal , Raymond G. Booth, and Drake Morgan
2012
Molecular Determinants for Ligand Binding at Serotonin 5-HT2A and 5-HT2C GPCRs: Experimental Affinity Results Analyzed by Molecular Modeling and Ligand Docking Studies
Tania Córdova-Sintjago, Rajeev Sakhuja, Krishnakanth Kondabolu, Clinton E Canal, and Raymond G. Booth
Molecular determinants of ligand binding at the human histamine H1 receptor: Site-directed mutagenesis results analyzed with ligand docking and molecular dynamics studies at H1 homology and crystal structure models
Tania C. Cordova-Sintjago, Lijuan Fang, Martijn Bruysters, Rob Leurs, and Raymond G. Booth
2011
Drug discovery targeting human 5-HT(2C) receptors: residues S3.36 and Y7.43 impact ligand-binding pocket structure via hydrogen bond formation
Clinton E. Canal, Tania C. Cordova-Sintjago, Nancy Y. Villa, Li-Juan Fang, and Raymond G. Booth
A novel potential therapeutic avenue for autism: design, synthesis and pharmacophore generation of SSRIs with dual action
Ola M. Ghoneim, Diaa A. Ibrahim, Ibrahim M. El-Deeb, So Ha Lee, and Raymond G. Booth
2009
New Approach to 4-Phenyl-β-aminotetralin from 4-(3-Halophenyl)tetralen-2-ol Phenylacetate
Adam S. Vincek and Raymond G. Booth
(1R, 3S)-(-)-trans-PAT: a novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity
Raymond G. Booth, Lijuan Fang, Yingsu Huang, Andrzej Wilczynski, and Sashikala Sivendran
2008
Effect of (-)-trans-PAT, a novel 5-HT2C receptor agonist, on intake of palatable food in mice
Neil E. Rowland, Erica M. Crump, Nancy Nguyen, Kimberly Robertson, Zhuming Sun, Raymond G. Booth
Molecular determinants of ligand-directed signaling for the histamine H1 receptor
Raymond G. Booth, L. Fang, A. Wilczynski, S. Sivendren, Z. Sun, S. Travers, M. Bruysters, K. Sansuk, and R. Leurs
2007
Novel ligands stabilize stereo-selective conformations of the histamine H1 receptor to activate catecholamine synthesis
Raymond G. Booth and N. H. Moniri
2006
Role of PKA and PKC in histamine H1 receptor-mediated activation of catecholamine neurotransmitter synthesis
Nader H. Moniri and Raymond G. Booth
Novel ligands for the human histamine H1 receptor: synthesis, pharmacology, and comparative molecular field analysis studies of 2-dimethylamino-5-(6)-phenyl-1,2,3,4-tetrahydronaphthalenes
Ola M. Ghoneim, Jacqueline A. Legere, Alexander Golbraikh, Alexander Tropsha, and Raymond G. Booth
2005
Ligand-directed multifunctional signaling of histamine H1 receptors
Raymond G. Booth and N. H. Moniri
Neuronal nitric oxide modulates morphine antinociceptive tolerance by enhancing constitutive activity of the mu-opioid receptor
Erin L. Heinzen, Raymond G. Booth, and Gary M. Pollack
2004
Ligand-directed functional heterogeneity of histamine H1 receptors: novel dual-function ligands selectively activate and block H1-mediated phospholipase C and adenylyl cyclase signaling
Nader H. Moniri, Dawn Covington-Strachan, and Raymond G. Booth
Domain swapping in the human histamine H1 receptor
Remko A. Bakker, Guido Dees, Juan J. Carrillo, Raymond G. Booth, Juan F. López-Gimenez, Graeme Milligan, Philip G. Strange, and Rob Leurs
Functional heterogeneity of histamine H(1) receptors
N. H. Moniri and Raymond G. Booth
2002
A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors
Raymond G. Booth, Nader H. Moniri, Remko A. Bakker, Neepa Y. Choksi, William B. Nix, Henk Timmerman, and Rob Leurs
Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase
David M. Mottola, Jason D. Kilts, Mechelle M. Lewis, Hilary S. Connery, Q. David Walker, Sara R. Jones, Raymond G. Booth, Deborah K. Hyslop, Monford Piercey, R. Mark Wightman, Cindy P. Lawler, David E. Nichols, and Richard B. Mailman
2000
A novel phenylaminotetralin (PAT) recognizes histamine H1 receptors and stimulates dopamine synthesis in vivo in rat brain
Neepa Y Choksi, William B Nix, Steven D Wyrick, and Raymond G. Booth
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors
Ehren C. Bucholtz, Randal L. Brown, Alexander Tropsha, Raymond G. Booth, and Steven D. Wyrick
1999
Putative sigma(3) sites in mammalian brain have histamine H(1) receptor properties: evidence from ligand binding and distribution studies with the novel H(1) radioligand [(3)H]-(-)-trans-1-phenyl-3-aminotetralin
Raymond G. Booth, Constance E Owens, Randall L Brown, Ehren C Bucholtz, Cindy P Lawler, and Steven D Wyrick
1997
Effects of polychlorinated biphenyls (PCBs) on brain tyrosine hydroxylase activity and dopamine synthesis in rats
Neepa Y. Choksi, Prasada Rao S. Kodavanti, Hugh A. Tilson, and Raymond G. Booth
2-Phenylaminoadenosine stimulates dopamine synthesis in rat forebrain in vitro and in vivo via adenosine A2 receptors
Neepa Y Choksi, Anwar Hussain, and Raymond G. Booth
1995
1-Phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes and related derivatives as ligands for the neuromodulatory sigma 3 receptor: further structure-activity relationships
Steven D. Wyrick, Raymond G. Booth, Andrew M. Myers, Constance E. Owens, Ehren C. Bucholtz, Phillip C. Hooper, Nora S. Kula, Ross J. Baldessarini, and Richard B. Mailman
1994
Conformational analysis, pharmacophore identification, and comparative molecular field analysis of ligands for the neuromodulatory sigma 3 receptor
Andrew M. Myers, Paul S. Charifson, Constance E. Owens, Nora S. Kula, Andrew T. McPhail, Ross J. Baldessarini, Raymond G. Booth, and Steven D. Wyrick
Actions of (+/-)-7-hydroxy-N,N-dipropylaminotetralin (7-OH-DPAT) on dopamine synthesis in limbic and extrapyramidal regions of rat brain
Raymond G. Booth, Ross J. Baldessarini, Elda Marsh, and Constance E. Owens
1993
New sigma-like receptor recognized by novel phenylaminotetralins: ligand binding and functional studies
Raymond G. Booth, S D Wyrick, R J Baldessarini, N S Kula, A M Myers, and R B Mailman
Synthesis and pharmacological evaluation of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for a novel receptor with sigma-like neuromodulatory activity
Steven D. Wyrick, Raymond G. Booth, Andrew M. Myers, Constance E. Owens, Nora S. Kula, Ross J. Baldessarini, Andrew T. McPhail, and Richard B. Mailman
1991
Dopamine D1 autoreceptor function: possible expression in developing rat prefrontal cortex and striatum
Martin H. Teicher, Amelia L. Gallitano, Harris A. Gelbard, Henriette K. Evans, Elda R. Marsh, Raymond G. Booth, and Ross J. Baldessarini
(+)-6,7-benzomorphan sigma ligands stimulate dopamine synthesis in rat corpus striatum tissue
Raymond G. Booth and Ross J. Baldessarini
Inhibition of dopamine synthesis in rat striatal minces: evidence of dopamine autoreceptor supersensitivity to S(+)- but not R(-)-N-n-propylnorapomorphine after pretreatment with fluphenazine
Raymond G. Booth, Ross J. Baldessarini, and Alexander Campbell
1990
Adenosine A2 stimulation of tyrosine hydroxylase in rat striatal minces is reversed by dopamine D2 autoreceptor activation
Raymond G. Booth and Ross J. Baldessarini
In vivo intracerebral microdialysis studies in rats of MPP+ analogues and related charged species
Hans Rollema, E. Anne Johnson, Raymond G. Booth, Patricia Caldera, Peter Lampen, Stephen K. Youngster, Anthony J. Trevor, Noreen Naiman, and Neal Castagnoli Jr.
Presynaptic inhibition of dopamine synthesis in rat striatal tissue by enantiomeric mono- and dihydroxyaporphines
Raymond G. Booth, R J Baldessarini, N S Kula, Y Gao, R Zong, and J L Neumeyer
1989
1-methyl-4-phenylpyridinium (MPP+) analogs: in vivo neurotoxicity and inhibition of striatal synaptosomal dopamine uptake
E.Anne Johnson, Ellen Y. Wu, Hans Rollema, Raymond G. Booth, Anthony J. Trevor, and Neal Castagnoli Jr.
Intracerebral microdialysis neurotoxicity studies of quinoline and isoquinoline derivatives related to MPTP/MPP+
Raymond G. Booth, Neal Castagnoli Jr., and Hans Rollema
Studies on semirigid tricyclic analogues of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Raymond G. Booth, Anthony Trevor, Thomas P. Singer, and Neal Castagnoli Jr.
1988
Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines
Worachart Sirawaraporn, Rachada Sertsrivanich, Raymond G. Booth, Corwin Hansch, R.A. Neal, and Daniel V. Santi
In vivo dopaminergic neurotoxicity of the 2-beta-methylcarbolinium ion, a potential endogenous MPP+ analog
Hans Rollema, Raymond G. Booth, and Neal Castagnoli Jr.
1987
Inhibition of NADH oxidation by pyridine derivatives
Rona R. Ramsay, Kathleen A. McKeown, Elizabeth Anne Johnson, Raymond G. Booth, and Thomas P. Singer
Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth
Raymond G. Booth, Cynthia Dias Selassie, Corwin Hansch, and Daniel V. Santi